Efficiency of Bridging-Sheet Recruitment Explains HIV-1 R5 Envelope Glycoprotein Sensitivity to Soluble CD4 and Macrophage Tropism

HIV-1 R5 viruses vary extensively in their capacity to infect macrophages. R5 viruses that confer efficient infection of macrophages are able to exploit low levels of CD4 for infection and predominate in brain tissue, where macrophages are a major target for infection. HIV-1 R5 founder viruses that...

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Detalhes bibliográficos
Main Authors: O'Connell, Olivia, Repik, Alexander, Reeves, Jacqueline D., Gonzalez-Perez, Maria Paz, Quitadamo, Briana, Anton, Elizabeth D., Duenas-Decamp, Maria, Peters, Paul, Lin, Rongheng, Zolla-Pazner, Susan, Corti, Davide, Wallace, Aaron, Wang, Shixia, Kong, Xiang-Peng, Lu, Shan, Clapham, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536387/
https://ncbi.nlm.nih.gov/pubmed/23055568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01834-12
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