Efficiency of Bridging-Sheet Recruitment Explains HIV-1 R5 Envelope Glycoprotein Sensitivity to Soluble CD4 and Macrophage Tropism

HIV-1 R5 viruses vary extensively in their capacity to infect macrophages. R5 viruses that confer efficient infection of macrophages are able to exploit low levels of CD4 for infection and predominate in brain tissue, where macrophages are a major target for infection. HIV-1 R5 founder viruses that...

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Dettagli Bibliografici
Autori principali: O'Connell, Olivia, Repik, Alexander, Reeves, Jacqueline D., Gonzalez-Perez, Maria Paz, Quitadamo, Briana, Anton, Elizabeth D., Duenas-Decamp, Maria, Peters, Paul, Lin, Rongheng, Zolla-Pazner, Susan, Corti, Davide, Wallace, Aaron, Wang, Shixia, Kong, Xiang-Peng, Lu, Shan, Clapham, Paul R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536387/
https://ncbi.nlm.nih.gov/pubmed/23055568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01834-12
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