Enrichment-based DNA methylation analysis using next-generation sequencing: sample exclusion, estimating changes in global methylation, and the contribution of replicate lanes

BACKGROUND: DNA methylation is an important epigenetic mark and dysregulation of DNA methylation is associated with many diseases including cancer. Advances in next-generation sequencing now allow unbiased methylome profiling of entire patient cohorts, greatly facilitating biomarker discovery and pr...

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Hlavní autoři: Trimarchi, Michael P, Murphy, Mark, Frankhouser, David, Rodriguez, Benjamin AT, Curfman, John, Marcucci, Guido, Yan, Pearlly, Bundschuh, Ralf
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535705/
https://ncbi.nlm.nih.gov/pubmed/23281662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-S8-S6
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