Trypanosoma brucei Orc1 Is Essential for Nuclear DNA Replication and Affects Both VSG Silencing and Switching

Binding of the Origin Recognition Complex (ORC) to replication origins is essential for initiation of DNA replication, but ORC has non-essential functions outside of DNA replication, including in heterochromatic gene silencing and telomere maintenance. Trypanosoma brucei, a protozoan parasite that c...

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Autors principals: Benmerzouga, Imaan, Concepción-Acevedo, Jeniffer, Kim, Hee-Sook, Vandoros, Anthula V., Cross, George A.M., Klingbeil, Michele M., Li, Bibo
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535549/
https://ncbi.nlm.nih.gov/pubmed/23216794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12093
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