Extracellular and Intracellular Esterase Processing of SCFA-Hexosamine Analogs: Implications for Metabolic Glycongineering and Drug Delivery

This report provides a synopsis of the esterase processing of short chain fatty acid (SCFA)-derivatized hexosamine analogs used in metabolic glycoengineering by demonstrating that the extracellular hydrolysis of these compounds is comparatively slow (e.g., with a t(1/2) of ~ 4 hours to several days)...

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Main Authors: Mathew, Mohit P., Tan, Elaine, Shah, Shivam, Bhattacharya, Rahul, Meledeo, M. Adam, Huang, Jun, Espinoza, Freddy A., Yarema, Kevin J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530194/
https://ncbi.nlm.nih.gov/pubmed/23041156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.09.017
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