CRACM/Orai ion channel expression and function in human lung mast cells

BACKGROUND: Influx of extracellular Ca(2+) into human lung mast cells (HLMCs) is essential for the FcεRI-dependent release of preformed granule-derived mediators and newly synthesized autacoids and cytokines. However, the identity of the ion channels underlying this Ca(2+) influx is unknown. The rec...

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Главные авторы: Ashmole, Ian, Duffy, S. Mark, Leyland, Mark L., Morrison, Valerie S., Begg, Malcolm, Bradding, Peter
Формат: Artigo
Язык:Inglês
Опубликовано: Mosby 2012
Предметы:
Mechanisms of Allergy and Clinical Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526795/
https://ncbi.nlm.nih.gov/pubmed/22409987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2012.01.070
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