Cell-Extrinsic Effects of Tumor ER Stress Imprint Myeloid Dendritic Cells and Impair CD8(+) T Cell Priming

Tumor-infiltrating myeloid cells, such as dendritic cells (BMDC), are key regulators of tumor growth. However, the tumor-derived signals polarizing BMDC to a phenotype that subverts cell-mediated anti-tumor immunity have yet to be fully elucidated. Addressing this unresolved problem we show that the...

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Bibliographic Details
Main Authors: Mahadevan, Navin R., Anufreichik, Veronika, Rodvold, Jeffrey J., Chiu, Kevin T., Sepulveda, Homero, Zanetti, Maurizio
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525659/
https://ncbi.nlm.nih.gov/pubmed/23272178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051845
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