Transforming growth factor β(1 )inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy?

BACKGROUND: Bone morphogenic proteins (BMPs) play a key role in bone formation. Consequently, it was expected that topical application of recombinant human (rh)BMP-2 and rhBMP-7 would improve the healing of complex fractures. However, up to 36% of fracture patients do not respond to this therapy. Th...

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Main Authors: Ehnert, Sabrina, Zhao, Jian, Pscherer, Stefan, Freude, Thomas, Dooley, Steven, Kolk, Andreas, Stöckle, Ulrich, Nussler, Andreas Klaus, Hube, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523027/
https://ncbi.nlm.nih.gov/pubmed/22958403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-10-101
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