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Molecular Modeling Study on Tunnel Behavior in Different Histone Deacetylase Isoforms

Histone deacetylases (HDACs) have emerged as effective therapeutic targets in the treatment of various diseases including cancers as these enzymes directly involved in the epigenetic regulation of genes. However the development of isoform-selective HDAC inhibitors has been a challenge till date sinc...

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Detalhes bibliográficos
Main Authors: Thangapandian, Sundarapandian, John, Shalini, Lee, Yuno, Arulalapperumal, Venkatesh, Lee, Keun Woo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510210/
https://ncbi.nlm.nih.gov/pubmed/23209570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049327
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