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The liver-specific tumor suppressor STAT5 controls expression of the ROS generating enzyme NOX4 and the pro-apoptotic proteins PUMA and BIM
Loss of STAT5 from liver tissue results in hepatosteatosis and enhanced cell proliferation. This study now demonstrates that liver-specific Stat5-null mice develop severe hepatosteatosis as well as hepatocellular carcinomas at 17 months of age even in the absence of chemical insults. To understand S...
Sparad:
| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3505809/ https://ncbi.nlm.nih.gov/pubmed/22711600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25900 |
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