Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages

Inflammatory neovascularization, such as choroidal neovascularization (CNV), occur in the presence of Notch expressing macrophages. DLL4s anti-angiogenic effect on endothelial cells (EC) has been widely recognized, but its influence on Notch signaling on macrophages and its overall effect in inflamm...

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Autori principali: Camelo, Serge, Raoul, William, Lavalette, Sophie, Calippe, Bertrand, Cristofaro, Brunella, Levy, Olivier, Houssier, Marianne, Sulpice, Eric, Jonet, Laurent, Klein, Christophe, Devevre, Estelle, Thuret, Gilles, Duarte, Antonio, Eichmann, Anne, Leconte, Laurence, Guillonneau, Xavier, Sennlaub, Florian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2012
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496480/
https://ncbi.nlm.nih.gov/pubmed/22869002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-012-9290-0
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