Chronic hypoxia and VEGF differentially modulate abundance and organization of myosin heavy chain isoforms in fetal and adult ovine arteries

Chronic hypoxia increases vascular endothelial growth factor (VEGF) and thereby promotes angiogenesis. The present study explores the hypothesis that hypoxic increases in VEGF also remodel artery wall structure and contractility through phenotypic transformation of smooth muscle. Pregnant and nonpre...

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Bibliografiske detaljer
Main Authors: Hubbell, Margaret C., Semotiuk, Andrew J., Thorpe, Richard B., Adeoye, Olayemi O., Butler, Stacy M., Williams, James M., Khorram, Omid, Pearce, William J.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492831/
https://ncbi.nlm.nih.gov/pubmed/22992677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00408.2011
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