A MYRISTOYL/PHOSPHOSERINE SWITCH CONTROLS cAMP-DEPENDENT PROTEIN KINASE ASSOCIATION TO MEMBRANES

The cAMP-dependent protein kinase (PKA) mediates a myriad of cellular signaling events and its activity is tightly regulated both in space and time. Among these regulatory mechanisms is N-myristoylation, whose biological role has been elusive. Using a combination of thermodynamics, kinetics, and spe...

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Bibliografiske detaljer
Main Authors: Gaffarogullari, Ece C., Masterson, Larry R., Metcalfe, Emily E., Traaseth, Nathaniel J., Balatri, Erica, Musa, Musa M., Mullen, Daniel, Distefano, Mark D., Veglia, Gianluigi
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487414/
https://ncbi.nlm.nih.gov/pubmed/21740913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.06.034
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