Sustained Submicromolar H(2)O(2) Levels Induce Hepcidin via Signal Transducer and Activator of Transcription 3 (STAT3)

The peptide hormone hepcidin regulates mammalian iron homeostasis by blocking ferroportin-mediated iron export from macrophages and the duodenum. During inflammation, hepcidin is strongly induced by interleukin 6, eventually leading to the anemia of chronic disease. Here we show that hepatoma cells...

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Détails bibliographiques
Auteurs principaux: Millonig, Gunda, Ganzleben, Ingo, Peccerella, Teresa, Casanovas, Guillem, Brodziak-Jarosz, Lidia, Breitkopf-Heinlein, Katja, Dick, Tobias P., Seitz, Helmut-Karl, Muckenthaler, Martina U., Mueller, Sebastian
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481342/
https://ncbi.nlm.nih.gov/pubmed/22932892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.358911
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