The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells

BACKGROUND: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the isoforms have distinct roles in different linea...

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Autori principali: Halsey, Christina, Docherty, Marie, McNeill, Mhairi, Gilchrist, Derek, Le Brocq, Michelle, Gibson, Brenda, Graham, Gerard
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Short Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476960/
https://ncbi.nlm.nih.gov/pubmed/22853316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-5-45
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