CCT244747 is a novel, potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs

PURPOSE: Many tumors exhibit defective cell cycle checkpoint control and increased replicative stress. CHK1 is critically involved in the DNA damage response and maintenance of replication fork stability. We have therefore discovered a novel, potent, highly selective, orally active, ATP competitive...

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Bibliografiske detaljer
Main Authors: Walton, Mike I, Eve, Paul D, Hayes, Angela, Valenti, Melanie R, De Haven Brandon, Alexis K, Box, Gary, Hallsworth, Albert, Smith, Elizabeth L, Boxall, Kathy J, Lainchbury, Michael, Matthews, Thomas P, Jamin, Yann, Robinson, Simon P, Aherne, G Wynne, Reader, John C, Chesler, Louis, Raynaud, Florence I, Eccles, Suzanne A, Collins, Ian, Garrett, Michelle D
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474704/
https://ncbi.nlm.nih.gov/pubmed/22929806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1322
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