IPLEX Administration Improves Motor Neuron Survival and Ameliorates Motor Functions in a Severe Mouse Model of Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is an inherited neurodegenerative disorder and the first genetic cause of death in childhood. SMA is caused by low levels of survival motor neuron (SMN) protein that induce selective loss of α-motor neurons (MNs) in the spinal cord, resulting in progressive muscle atrop...

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Main Authors: Murdocca, Michela, Malgieri, Arianna, Luchetti, Andrea, Saieva, Luciano, Dobrowolny, Gabriella, de Leonibus, Elvira, Filareto, Antonio, Quitadamo, Maria Chiara, Novelli, Giuseppe, Musarò, Antonio, Sangiuolo, Federica
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474434/
https://ncbi.nlm.nih.gov/pubmed/22669476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2012.00056
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