Estrogen Metabolism and Exposure in a Genotypic-Phenotypic Model for Breast Cancer Risk Prediction

BACKGROUND: Current models of breast cancer risk prediction do not directly reflect mammary estrogen metabolism or genetic variability in exposure to carcinogenic estrogen metabolites. METHODS: We developed a model that simulates the kinetic effect of genetic variants of the enzymes CYP1A1, CYP1B1,...

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Detalhes bibliográficos
Main Authors: Crooke, Philip S., Justenhoven, Christina, Brauch, Hiltrud, Dawling, Sheila, Roodi, Nady, Higginbotham, Kathryn S. P., Plummer, W. Dale, Schuyler, Peggy A., Sanders, Melinda E, Page, David L., Smith, Jeffrey R., Dupont, William D., Parl, Fritz F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472969/
https://ncbi.nlm.nih.gov/pubmed/21610218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-11-0060
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