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Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells

The development of human cancers is frequently associated with a failure of epithelial cells to form tight junctions and to establish proper apicobasal polarity. Interestingly, the oncogenic potential of the adenovirus E4-ORF1 protein correlates with its binding to the cellular PDZ proteins MUPP1, M...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Latorre, Isabel J., Roh, Michael H., Frese, Kristopher K., Weiss, Robert S., Margolis, Ben, Javier, Ronald T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2005
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471650/
https://ncbi.nlm.nih.gov/pubmed/16141229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.02560
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