Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells

Apurinic/apyrimidinic endonuclease 1 (APE1) is the main abasic endonuclease in the base excision repair (BER) pathway of DNA lesions caused by oxidation/alkylation in mammalian cells; within nucleoli it interacts with nucleophosmin and rRNA through N-terminal Lys residues, some of which (K(27)/K(31)...

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Detalhes bibliográficos
Main Authors: Lirussi, Lisa, Antoniali, Giulia, Vascotto, Carlo, D'Ambrosio, Chiara, Poletto, Mattia, Romanello, Milena, Marasco, Daniela, Leone, Marilisa, Quadrifoglio, Franco, Bhakat, Kishor K., Scaloni, Andrea, Tell, Gianluca
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469522/
https://ncbi.nlm.nih.gov/pubmed/22918947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-04-0299
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