Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway

The transforming growth factor-β (TGF-β) signalling pathway participates in various biological processes. Dysregulation of Smad4, a central cellular transducer of TGF-β signalling, is implicated in a wide range of human diseases and developmental disorders. However, the mechanisms underlying Smad4 d...

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Hlavní autoři: Zhang, Yan, Fan, Kai-Ji, Sun, Qiang, Chen, Ai-Zhong, Shen, Wen-Long, Zhao, Zhi-Hu, Zheng, Xiao-Fei, Yang, Xiao
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467063/
https://ncbi.nlm.nih.gov/pubmed/22821565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks667
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