Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated Phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates

The antioxidant response element (ARE) is a critical regulatory element for the expression of many phase II drug metabolizing enzymes (DME), phase III transporters, and anti-oxidant enzymes, mediated by the transcription factor Nrf2. The aim of this study was to examine the potential activation and...

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Main Authors: Saw, Constance Lay-Lay, Cintron, Melvilí, Wu, Tien-Yuan, Guo, Yue, Huang, Ying, Jeong, Woo-Sik, Kong, Ah-Ng Tony
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465716/
https://ncbi.nlm.nih.gov/pubmed/21656528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdd.759
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