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T-Cell Avidity and Tuning: The Flexible Connection Between Tolerance and Autoimmunity
Thymic T-cell selection mechanisms generate a cross-reactive, self-MHC restricted peripheral T-cell pool. Affinity and avidity are of profound influence on this selection and the generation of immunity. Autoreactive T cells can escape thymic deletion by lowering their avidity and retain this “tuned”...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3462655/ https://ncbi.nlm.nih.gov/pubmed/16818373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/08830180600743081 |
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