Astrocyte-derived CO is a diffusible messenger that mediates glutamate-induced cerebral arteriolar dilation by activating smooth muscle cell K(Ca) channels

Astrocyte signals can modulate arteriolar tone, contributing to regulation of cerebral blood flow, but specific intercellular communication mechanisms are unclear. Here we used isolated cerebral arteriole myocytes, astrocytes, and brain slices to investigate whether carbon monoxide (CO) generated by...

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Hlavní autoři: Li, Anlong, Xi, Qi, Umstot, Edward S., Bellner, Lars, Schwartzman, Michal L., Jaggar, Jonathan H., Leffler, Charles W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460645/
https://ncbi.nlm.nih.gov/pubmed/17991880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.107.164145
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