Ginsenoside Rb1 Prevents MPP(+)-Induced Apoptosis in PC12 Cells by Stimulating Estrogen Receptors with Consequent Activation of ERK1/2, Akt and Inhibition of SAPK/JNK, p38 MAPK

Ginsenoside Rb1 shows neuroprotective effects in various neurons, including dopaminergic cells. However, the precise mechanisms of action are uncertain. In this paper, we examine whether Rb1 has a neuroprotective effect on MPP(+)-induced apoptosis and attempt to clarify the signaling pathway in PC12...

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Hlavní autoři: Hashimoto, Ryo, Yu, Jing, Koizumi, Hideki, Ouchi, Yasuyoshi, Okabe, Tetsuro
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457685/
https://ncbi.nlm.nih.gov/pubmed/23024694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/693717
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