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Thermodynamic and Kinetics Analysis of Peptides Derived from CapZ, NDR, p53, HDM2, and HDM4 Binding to Human S100B

S100B is a member of the S100 subfamily of EF-hand proteins that has been implicated in malignant melanoma and neurodegenerative conditions such as Alzheimer's and Parkinson's disease. Calcium-induced conformational changes expose a hydrophobic binding cleft, facilitating interactions with...

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Main Authors: Wafer, Lucas N., Streicher, Werner W., McCallum, Scott A., Makhatadze, George I.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448795/
https://ncbi.nlm.nih.gov/pubmed/22913742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300865g
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