Interferon Response Factors 3 and 7 Protect against Chikungunya Virus Hemorrhagic Fever and Shock

Chikungunya virus (CHIKV) infections can produce severe disease and mortality. Here we show that CHIKV infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7(−/−)) is lethal. Mortality was associated with undetectable levels of alpha/beta interferon (IFN-α/β) in serum, ∼50-...

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Detalhes bibliográficos
Main Authors: Rudd, Penny A., Wilson, Jane, Gardner, Joy, Larcher, Thibaut, Babarit, Candice, Le, Thuy T., Anraku, Itaru, Kumagai, Yutaro, Loo, Yueh-Ming, Gale, Michael, Akira, Shizuo, Khromykh, Alexander A., Suhrbier, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446587/
https://ncbi.nlm.nih.gov/pubmed/22761364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00956-12
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