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Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell–cell adhesion
Nectins are members of the Ig superfamily that mediate cell–cell adhesion through homophilic and heterophilic interactions. We have determined the crystal structure of the nectin-2 homodimer at 1.3 Å resolution. Structural analysis and complementary mutagenesis studies reveal the basis for recogniti...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3443150/ https://ncbi.nlm.nih.gov/pubmed/22927415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212912109 |
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