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Identification and Proteomic Analysis of Distinct UBE3A/E6AP Protein Complexes

The E6AP ubiquitin ligase catalyzes the high-risk human papillomaviruses' E6-mediated ubiquitylation of p53, contributing to the neoplastic progression of cells infected by these viruses. Defects in the activity and the dosage of E6AP are linked to Angelman syndrome and to autism spectrum disor...

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Bibliografiske detaljer
Main Authors: Martínez-Noël, Gustavo, Galligan, Jeffrey T., Sowa, Mathew E., Arndt, Verena, Overton, Thomas M., Harper, J. Wade, Howley, Peter M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434508/
https://ncbi.nlm.nih.gov/pubmed/22645313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00201-12
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