Three Routes to Suppression of the Neurodegenerative Phenotypes Caused by Kinesin Heavy Chain Mutations

Kinesin-1 is a motor protein that moves stepwise along microtubules by employing dimerized kinesin heavy chain (Khc) subunits that alternate cycles of microtubule binding, conformational change, and ATP hydrolysis. Mutations in the Drosophila Khc gene are known to cause distal paralysis and lethalit...

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Bibliographic Details
Main Authors: Djagaeva, Inna, Rose, Debra J., Lim, Angeline, Venter, Chris E., Brendza, Katherine M., Moua, Pangkong, Saxton, William M.
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2012
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Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430534/
https://ncbi.nlm.nih.gov/pubmed/22714410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.112.140798
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