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Mitochondrial Dysfunction and Oxidative Stress Promote Apoptotic Cell Death in the Striatum via Cytochrome c/Caspase-3 Signaling Cascade Following Chronic Rotenone Intoxication in Rats
Parkinson’s disease (PD) is a progressive neurological disorder marked by nigrostriatal dopaminergic degeneration. Evidence suggests that mitochondrial dysfunction may be linked to PD through a variety of different pathways, including free-radical generation and dysfunction of the mitochondrial Comp...
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Main Authors: | , , , , , |
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格式: | Artigo |
語言: | Inglês |
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Molecular Diversity Preservation International (MDPI)
2012
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3430261/ https://ncbi.nlm.nih.gov/pubmed/22942730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms13078722 |
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