A Novel Long-Acting Human Growth Hormone Fusion Protein (VRS-317): Enhanced In Vivo Potency and Half-Life

A novel recombinant human growth hormone (rhGH) fusion protein (VRS-317) was designed to minimize receptor-mediated clearance through a reduction in receptor binding without mutations to rhGH by genetically fusing with XTEN amino acid sequences to the N-terminus and the C-terminus of the native hGH...

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Bibliografiske detaljer
Main Authors: Cleland, Jeffrey L, Geething, Nathan C, Moore, Jerome A, Rogers, Brian C, Spink, Benjamin J, Wang, Chai-Wei, Alters, Susan E, Stemmer, Willem P C, Schellenberger, Volker
Format: Artigo
Sprog:Inglês
Udgivet: Wiley Subscription Services, Inc., A Wiley Company 2012
Fag:
Biotechnology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427893/
https://ncbi.nlm.nih.gov/pubmed/22678811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23229
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