Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics

Medulloblastoma (MB) is the most common pediatric CNS malignancy. We identify EAG2 as an overexpressed potassium channel in MBs across different molecular and histological subgroups. EAG2 knockdown not only impairs MB cell growth in vitro, but also reduces tumor burden in vivo and enhances survival...

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Main Authors: Huang, Xi, Dubuc, Adrian M., Hashizume, Rintaro, Berg, Jim, He, Ye, Wang, Ji, Chiang, Chin, Cooper, Michael K., Northcott, Paul A., Taylor, Michael D., Barnes, Michael J., Tihan, Tarik, Chen, Justin, Hackett, Christopher S., Weiss, William A., James, C. David, Rowitch, David H., Shuman, Marc A., Jan, Yuh Nung, Jan, Lily Yeh
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2012
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426758/
https://ncbi.nlm.nih.gov/pubmed/22855790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.193789.112
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