Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics

Medulloblastoma (MB) is the most common pediatric CNS malignancy. We identify EAG2 as an overexpressed potassium channel in MBs across different molecular and histological subgroups. EAG2 knockdown not only impairs MB cell growth in vitro, but also reduces tumor burden in vivo and enhances survival...

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Autors principals: Huang, Xi, Dubuc, Adrian M., Hashizume, Rintaro, Berg, Jim, He, Ye, Wang, Ji, Chiang, Chin, Cooper, Michael K., Northcott, Paul A., Taylor, Michael D., Barnes, Michael J., Tihan, Tarik, Chen, Justin, Hackett, Christopher S., Weiss, William A., James, C. David, Rowitch, David H., Shuman, Marc A., Jan, Yuh Nung, Jan, Lily Yeh
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426758/
https://ncbi.nlm.nih.gov/pubmed/22855790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.193789.112
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