Reagent Precoated Targets for Rapid In-Tissue Derivatization of the Anti-Tuberculosis Drug Isoniazid Followed by MALDI Imaging Mass Spectrometry

Isoniazid (INH) is an important component of front-line anti-tuberculosis therapy with good serum pharmacokinetics but unknown ability to penetrate tuberculous lesions. However, endogenous background interferences hinder our ability to directly analyze INH in tissues. Chemical derivatization has bee...

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Hauptverfasser: Manier, M. Lisa, Reyzer, Michelle L., Goh, Anne, Dartois, Veronique, Via, Laura E., Barry, Clifton E., Caprioli, Richard M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424619/
https://ncbi.nlm.nih.gov/pubmed/21953196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-011-0150-8
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