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Biochemical and Genetic Evidence for a SAP-PKC-θ Interaction Contributing to IL-4 Regulation
SAP, an adaptor molecule that recruits Fyn to the SLAM-family of immunomodulatory receptors, is mutated in X-linked lymphoproliferative disease. CD4(+) T cells from SAP-deficient mice have defective TCR-induced IL-4 production and impaired T cell-mediated help for germinal center formation; however,...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3422635/ https://ncbi.nlm.nih.gov/pubmed/20668219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902182 |
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