Biochemical and Genetic Evidence for a SAP-PKC-θ Interaction Contributing to IL-4 Regulation

SAP, an adaptor molecule that recruits Fyn to the SLAM-family of immunomodulatory receptors, is mutated in X-linked lymphoproliferative disease. CD4(+) T cells from SAP-deficient mice have defective TCR-induced IL-4 production and impaired T cell-mediated help for germinal center formation; however,...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Cannons, Jennifer L., Wu, Julie Z., Gomez-Rodriguez, Julio, Zhang, Jinyi, Dong, Baoxia, Liu, Yin, Shaw, Stephen, Siminovitch, Katherine A., Schwartzberg, Pamela L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422635/
https://ncbi.nlm.nih.gov/pubmed/20668219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902182
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky