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Unexpected role for perforin in regulating contraction of CD8 and CD4 T cells during prolonged Listeria monocytogenes infection

After infection or vaccination, antigen-specific T cells proliferate then contract in numbers to a memory set point. T cell contraction is observed after both acute and prolonged infections although it is unknown if contraction is regulated similarly in both scenarios. Here, we show that contraction...

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Bibliografiske detaljer
Main Authors: Schmidt, Nathan W., Khanolkar, Aaruni, Hancox, Lisa, Heusel, Jonathan W., Harty, John T.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418886/
https://ncbi.nlm.nih.gov/pubmed/22161269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201141902
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