Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?

BACKGROUND AND PURPOSE: Terfenadine has been reported to cause cardiac death. Hence, we investigated its pro-arrhythmic potential in various in vitro models. EXPERIMENTAL APPROACH: Pro-arrhythmic effects of terfenadine were investigated in rabbit isolated hearts and left ventricular wedge preparatio...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Lu, Hua Rong, Hermans, An N, Gallacher, David J
פורמט: Artigo
שפה:Inglês
יצא לאור: Blackwell Publishing Ltd 2012
נושאים:
Research Papers
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417462/
https://ncbi.nlm.nih.gov/pubmed/22300168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01880.x
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