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Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1
Bortezomib (Velcade) is used widely for the treatment of various human cancers; however, its mechanisms of action are not fully understood, particularly in myeloid malignancies. Bortezomib is a selective and reversible inhibitor of the proteasome. Paradoxically, we find that bortezomib induces prote...
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Główni autorzy: | , , , , , , , , , , , , , , |
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Format: | Artigo |
Język: | Inglês |
Wydane: |
American Society of Hematology
2012
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412348/ https://ncbi.nlm.nih.gov/pubmed/22685174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-407999 |
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