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Racemization of Two Proteins over Our Lifespan: Deamidation of Asparagine 76 in γS Crystallin Is Greater in Cataract than in Normal Lenses across the Age Range

PURPOSE. Long-lived proteins are widespread in man, yet little is known about the processes that affect their function over time, or their role in age-related diseases. METHODS. Racemization of two proteins from normal and cataract human lenses were compared with age using tryptic digestion and LC/m...

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Bibliografske podrobnosti
Main Authors: Hooi, Michelle Yu Sung, Raftery, Mark J., Truscott, Roger John Willis
Format: Artigo
Jezik:Inglês
Izdano: The Association for Research in Vision and Ophthalmology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406884/
https://ncbi.nlm.nih.gov/pubmed/22531704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-9085
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