Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity

Two distinct Polycomb complexes, PRC1 and PRC2, collaborate to maintain epigenetic repression of key developmental loci in embryonic stem cells (ESCs). PRC1 and PRC2 have histone modifying activities, catalyzing mono-ubiquitination of histone H2A (H2AK119u1) and trimethylation of H3 lysine 27 (H3K27...

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Bibliographic Details
Main Authors: Endoh, Mitsuhiro, Endo, Takaho A., Endoh, Tamie, Isono, Kyo-ichi, Sharif, Jafar, Ohara, Osamu, Toyoda, Tetsuro, Ito, Takashi, Eskeland, Ragnhild, Bickmore, Wendy A., Vidal, Miguel, Bernstein, Bradley E., Koseki, Haruhiko
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405999/
https://ncbi.nlm.nih.gov/pubmed/22844243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002774
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