Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin

BACKGROUND: Acquiring clinically annotated, spatially stratified tissue samples from human glioblastoma (GBM) is compromised by haemorrhage, brain shift and subjective identification of ‘normal’ brain. We tested the use of 5-aminolevulinic acid (5-ALA) fluorescence to objective tissue sampling and t...

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Detalhes bibliográficos
Main Authors: Piccirillo, S G M, Dietz, S, Madhu, B, Griffiths, J, Price, S J, Collins, V P, Watts, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405212/
https://ncbi.nlm.nih.gov/pubmed/22722315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.271
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