Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis

Transient Receptor Potential Melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-threonine kinase domain. Here, we find that Trpm7(−/−) T-cells are deficient in Fas-receptor induced apoptosis; TRPM7 channel activity participates in the apoptotic process and is regul...

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Hauptverfasser: Desai, Bimal N., Krapivinsky, Grigory, Navarro, Betsy, Krapivinsky, Luba, Carter, Brett C., Febvay, Sebastien, Delling, Markus, Penumaka, Anirudh, Ramsey, I. Scott, Manasian, Yunona, Clapham, David E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397829/
https://ncbi.nlm.nih.gov/pubmed/22698280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.04.006
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