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Mechanism of Tissue-specific Farnesoid X Receptor in Suppressing the Expression of Genes in Bile-acid Synthesis in Mice
Activation of farnesoid X receptor (Fxr, Nr1h4) is a major mechanism in suppressing bile-acid synthesis by reducing the expression levels of genes encoding key bile-acid synthetic enzymes, CYP7A1/Cyp7a1 and CYP8B1/Cyp8b1. FXR-mediated induction of hepatic small heterodimer partner (SHP/Shp, Nr0b2) a...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3390456/ https://ncbi.nlm.nih.gov/pubmed/22467244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25740 |
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