Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death

Elevating Akt activation is an obvious clinical strategy to prevent progressive neuronal death in neurological diseases. However, this endeavor has been hindered because of the lack of specific Akt activators. Here, from a cell-based high-throughput chemical genetic screening, we identified a small...

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Detalhes bibliográficos
Main Authors: Jo, Hakryul, Mondal, Subhanjan, Tan, Dewar, Nagata, Eiichiro, Takizawa, Shunya, Sharma, Alok K., Hou, Qingming, Shanmugasundaram, Kumaran, Prasad, Amit, Tung, Joe K., Tejeda, Alexander O., Man, Hengye, Rigby, Alan C., Luo, Hongbo R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387065/
https://ncbi.nlm.nih.gov/pubmed/22689977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202810109
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