Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death

Elevating Akt activation is an obvious clinical strategy to prevent progressive neuronal death in neurological diseases. However, this endeavor has been hindered because of the lack of specific Akt activators. Here, from a cell-based high-throughput chemical genetic screening, we identified a small...

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Bibliographische Detailangaben
Hauptverfasser: Jo, Hakryul, Mondal, Subhanjan, Tan, Dewar, Nagata, Eiichiro, Takizawa, Shunya, Sharma, Alok K., Hou, Qingming, Shanmugasundaram, Kumaran, Prasad, Amit, Tung, Joe K., Tejeda, Alexander O., Man, Hengye, Rigby, Alan C., Luo, Hongbo R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387065/
https://ncbi.nlm.nih.gov/pubmed/22689977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202810109
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