Inhibition of Ca(2+)/Calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in Rats

BACKGROUND: Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes severe peripheral neuropathy. We previously reported that oxaliplatin (4 mg/kg, i.p., twice a week) induces mechanical allodynia in the late phase in rats, and that spinal NR2B-containig N-methyl-(D)-aspartate...

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Главные авторы: Shirahama, Masafumi, Ushio, Soichiro, Egashira, Nobuaki, Yamamoto, Shota, Sada, Hikaru, Masuguchi, Ken, Kawashiri, Takehiro, Oishi, Ryozo
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2012
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384243/
https://ncbi.nlm.nih.gov/pubmed/22510452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-26
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