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DIRECT INDUCTION OF APOPTOSIS USING AN OPTIMAL MITOCHONDRIALLY TARGETED P53
Targeting the tumor suppressor p53 to the mitochondria triggers a rapid apoptotic response as efficiently as transcription-dependent p53.(1, 2) p53 forms a complex with the anti-apoptotic Bcl-XL, which leads to Bak and Bax oligomerization resulting in apoptosis via mitochondrial outer membrane perme...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3377387/ https://ncbi.nlm.nih.gov/pubmed/22380534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp3000259 |
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