The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5′Untranslated-Region-Directed Translation Blockers of the Parkinson's Alpha Synuclein Expression

There is compelling support for limiting expression of alpha-synuclein (α-syn) in the brains of Parkinson's disease (PD) patients. An increase of SNCA gene copy number can genetically cause familial PD where increased dose of this pathogenic protein correlates with severity of symptoms (triplic...

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Hlavní autoři: Mikkilineni, Sohan, Cantuti-Castelvetri, Ippolita, Cahill, Catherine M., Balliedier, Amelie, Greig, Nigel H., Rogers, Jack T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368596/
https://ncbi.nlm.nih.gov/pubmed/22693681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/142372
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